With California and other states likely to vote on full cannabis legalization, decisions made in 2016 may well shape the future of cannabis policy for a generation or more. Scientists, policy thinkers, journalists, industry leaders, and advocates came together at the Cannabis Science and Policy Summit 2016 on April 17 and 18 in New York City for a discussion of what is happening, what is likely to happen, and what should be done in the world of cannabis legalization. Martin Jelsma and Tom Blickman of TNI participated in two different panels.